Diagnostic performance of alpha-fetoprotein, YKL40 and GP73 in hepatocellular carcinoma Egyptian patients

Because primary liver cancer is a growing concern showing poor prognosis due to its rapid infiltrating power and complicating liver cirrhosis; more attention were given to address the causal risk factors that could be preventable and/or treatable. 2 HCC is phenotypically and genetically heterogeneous tumor, reflecting in part the heterogeneity of etiologic factors involved in (i) the onset of HCC development that is also influenced by age, gender and ethnic differences, (ii) the complexity of hepatocyte functions and epigenome leading to neo-plastic transformation and (iii) the late stage of HCC development. 3